The phrase "to run a route" means to follow a specific path or direction while traveling or delivering something, typically as part of a job or activity.
Sentences with «to run a route»
Obviously, there are some great run routes in all of them that I need to check out! (marontherun.com)
As a fan, watching those guys just running routes on game day is not as exciting as when they start receiving those balls. (sbnation.com)
He can't run routes or catch passes and he is only allowed 2 hours in the building. (sbnation.com)